Passage of amyloid β protein antibody across the blood–brain barrier in a mouse model of Alzheimer's disease
Vaccinations against amyloid β protein (AβP) reduce amyloid deposition and reverse
learning and memory deficits in mouse models of Alzheimer's disease. This has raised the
question of whether circulating antibodies, normally restricted by the blood–brain barrier
(BBB), can enter the brain [Nat. Med. 7 (2001) 369–372]. Here, we show that antibody
directed against AβP does cross the BBB at a very low rate. Entry is by way of the
extracellular pathways with about 0.11% of an intravenous (iv) dose entering the brain by …
learning and memory deficits in mouse models of Alzheimer's disease. This has raised the
question of whether circulating antibodies, normally restricted by the blood–brain barrier
(BBB), can enter the brain [Nat. Med. 7 (2001) 369–372]. Here, we show that antibody
directed against AβP does cross the BBB at a very low rate. Entry is by way of the
extracellular pathways with about 0.11% of an intravenous (iv) dose entering the brain by …